We review concepts from Carroll Quigley's Tragedy and Hope (1966), a seminal work on the life cycles of civilizations. America now seems mired in an "age of conflict" marked by class struggles, irrationality, and culture wars. Can there be a new "age of expansion" or will we enter into a "universal empire"? Only the American system of political economy holds the keys to rebuilding an economy and cultural solidarity. Will the Biden administration seize their historical opportunity to build our way out of crisis?